The move gives McAfee a suite of software, services and hardware products to protect hackers from getting past the perimeters of computer networks.
McAfee is already the No. 2 provider of anti-virus software. Symantec is the largest.
Santa Clara, California-based McAfee will pay $5.75 per share of Secure Computing's common stock, representing a 27 percent premium to the San Jose, California company's closing price of $4.52 on Friday.
Secure Computing shares were quoted at $5.59 in pre-market trade.
The companies expect the transaction to close at the end of the fourth quarter of this year.